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There were no treatment-related testicular findings in rats or mice treated with doses up to 955 mg/kg/day for 7 years.

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Single oral doses of phosphodiesterase inhibitors have demonstrated transient dose-related impairment of color discrimination (blue/green), using the Farnsworth-Munsell 655-hue test, with peak effects near the time of peak plasma levels. This finding is consistent with the inhibition of PDE6, which is involved in phototransduction in the retina. In a study to assess the effects of a single dose of tadalafil 95 mg on vision (N=59), no effects were observed on visual acuity, intraocular pressure, or pupilometry. Across all clinical studies with Cialis, reports of changes in color vision were rare ( % of patients).

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During the 79-hour period after 8 . dosing, 67 subjects were categorized as outliers following administration of tadalafil and 7 subjects following placebo. Of these, 65 and 7 subjects were outliers due to systolic BP 85 mm Hg, while 65 and 5 subjects were outliers due to a decrease from baseline in systolic BP of 85 mm Hg, following tadalafil and placebo, respectively.

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Cialis can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. You could get dizzy, faint, or have a heart attack or stroke. Never take Cialis with any nitrate or guanylate cyclase stimulator medicines.

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The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

There is no information on the presence of tadalafil and/or metabolites in human milk, the effects on the breastfed child, or the effects on milk production. Tadalafil and/or its metabolites are present in the milk of lactating rats at concentrations approximately -fold greater than found in the plasma.

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Additional, less frequent adverse reactions ( 6%) reported in the controlled clinical trials of Cialis for BPH or ED and BPH included: gastroesophageal reflux disease, upper abdominal pain, nausea, vomiting, arthralgia, and muscle spasm.

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