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Publication date: 2018-05-19 16:03

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Administration of CIALIS to patients who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, CIALIS was shown to potentiate the hypotensive effect of nitrates [see CLINICAL PHARMACOLOGY ].

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The mean apparent volume of distribution following oral administration is approximately 68 L, indicating that tadalafil is distributed into tissues. At concentrations, 99% of tadalafil in plasma is bound to proteins.

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Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces (approximately 66% of the dose) and to a lesser extent in the urine (approximately 86% of the dose).

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Physicians should discuss with patients the contraindication of CIALIS with regular and/or intermittent use of organic nitrates. Patients should be counseled that concomitant use of CIALIS with nitrates could cause blood pressure to suddenly drop to an unsafe level, resulting in dizziness, syncope , or even heart attack or stroke.

In these patients, the recommended dose is 5mg taken once a day at approximately the same time of day. The dose may be decreased to once a day based on individual tolerability.

Three clinical studies were conducted in 6559 patients in an at-home setting to define the period of responsiveness to CIALIS on demand. Tadalafil demonstrated statistically significant improvement in erectile function and the ability to have successful sexual intercourse up to 86 hours following dosing, as well as patients' ability to attain and maintain erections for successful intercourse compared to placebo as early as 66 minutes following dosing.

Physicians should discuss with patients the contraindication of CIALIS with any use of a GC stimulator, such as riociguat, for pulmonary arterial hypertension. Patients should be counseled that the concomitant use of CIALIS with GC stimulators may cause blood pressure to drop to an unsafe level.

Tadalafil administered to healthy subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (mean maximal decrease of /, respectively), in standing systolic and diastolic blood pressure (mean maximal decrease of /, respectively), and no significant change in heart rate.

Tadalafil was not mutagenic in the in vitro bacterial Ames assays or the forward mutation test in mouse lymphoma cells. Tadalafil was not clastogenic in the in vitro chromosomal aberration test in human lymphocytes or the in vivo rat micronucleus assays.

CIALIS for once daily use has not been extensively evaluated in patients with mild or moderate hepatic impairment. Therefore, caution is advised if CIALIS for once daily use is prescribed to these patients. Because of insufficient information in patients with severe hepatic impairment, use of CIALIS in this group is not recommended [see Use In Specific Populations ].

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Canadian Pharmacy CIALIS EXTRA LOW PRICES Use Cialis daily

Buy Cialis Online! All problems with erection stay in past from the very moment you purchase Cialis in our online shop! CIALIS for Once Daily Use for Erectile Dysfunction. The recommended starting dose of CIALIS for once daily use is mg, taken at approximately the same