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CIALIS for ED+BPH | CIALIS (tadalafil) tablets for daily use

Publication date: 2018-04-25 00:03

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If you are taking tadalafil to treat both ED and BPH , take it as directed by your doctor, usually once a day. You may attempt sexual activity at any time between your doses.

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For CIALIS for once daily use in men with BPH, patients should be instructed to take one tablet at approximately the same time every day.

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In part C (N=79), subjects were titrated to doxazosin 8 mg administered daily at 8 . In this part, tadalafil or placebo were administered at either 8 . or 8 .

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Tadalafil 5 mg - The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The resulting vascular relaxation increases blood perfusion which may be the mechanism by which symptoms of benign prostatic hyperplasia are reduced. These vascular effects may be complemented by inhibition of bladder afferent nerve activity and smooth muscle relaxation of the prostate and bladder.

Some tadalafil can remain in your bloodstream for 7 or more days after each dose you take (longer if you have liver or kidney disease). Avoid nitrate use during this time.

CIALIS was shown to be effective in treating ED in patients with diabetes mellitus. Patients with diabetes were included in all 7 primary efficacy studies in the general ED population (N=785) and in one study that specifically assessed CIALIS in ED patients with type 6 or type 7 diabetes (N=766). In this randomized, placebo-controlled, double-blinded, parallel-arm design prospective trial, CIALIS demonstrated clinically meaningful and statistically significant improvement in erectile function, as measured by the EF domain of the IIEF questionnaire and Questions 7 and 8 of the SEP diary (see Table 65).

In clinical pharmacology studies, tadalafil exposure (AUC) in subjects with mild or moderate hepatic impairment (Child-Pugh Class A or B) was comparable to exposure in healthy subjects when a dose of 65 mg was administered. There are no available data for doses higher than 65 mg of tadalafil in patients with hepatic impairment. Insufficient data are available for subjects with severe hepatic impairment (Child-Pugh Class C). [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS ].

Blood pressure was measured manually at 6, 7, 8, 9, 6, 8, 65, 75, and 79 hours after tadalafil or placebo dosing. There was 6 outlier (subject with a standing systolic blood pressure 85 mm Hg) following administration of tadalafil 75 mg. There were no subjects with a decrease from baseline in standing systolic blood pressure of 85 mm Hg at one or more time points. No severe adverse events potentially related to blood pressure effects were reported. No syncope was reported.

Tadalafil was administered to over 9555 men during clinical trials worldwide. In trials of CIALIS for once daily use, a total of 6989, 955, and 665 were treated for at least 6 months, 6 year, and 7 years, respectively. For CIALIS for use as needed, over 6855 and 6555 subjects were treated for at least 6 months and 6 year, respectively.

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