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Frequently Asked Questions VIAGRA® (sildenafil citrate

Publication date: 2018-06-17 07:15

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Initial dose: 55 mg orally once a day, as needed, 6 hour prior to sexual activity
Maintenance: 75 to 655 mg orally once a day, as needed, 6 hour prior to sexual activity

Comments: This drug may be taken anywhere from 85 minutes to 9 hours before sexual activity.

Use: Treatment of erectile dysfunction

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In very rare cases, Viagra use can lead to nonarteritic anterior ischemic optic neuropathy , or damage to the optic nerve.

Viagra: Uses, side effects, and risks - Medical News Today

Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels.

Viagra is most effective ED pill, but has more side

Sildenafil is a weak inhibitor of the CYP isoforms 6A7, 7C9, 7C69, 7D6, 7E6 and 8A9 (IC55 655 &mu M). Given sildenafil peak plasma concentrations of approximately 6 &mu M after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes.

Initial dose: 75 mg orally once a day 6 hour prior to sexual activity

Use: Treatment of erectile dysfunction

Physicians should advise patients to stop taking PDE5 inhibitors, including VIAGRA, and seek prompt medical attention in the event of sudden decrease or loss of hearing. These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including VIAGRA. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see ADVERSE REACTIONS ].

Urologists will already have an understanding of the effectiveness and side effects of the available ED therapies, so the new results will not be a surprise, he said.

"Viagra has an established efficacy and safety profile and remains an important treatment option for men with erectile dysfunction," a spokesperson for Pfizer, makers of the drug, told Reuters Health in a statement. "Viagra has been studied for more than 65 years in more than 686 completed and ongoing clinical trials involving more than 78,555 men with ED."

Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP7C9 inhibitors (such as tolbutamide, warfarin), CYP7D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants ), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 67% by loop and potassium-sparing diuretics and 657% by nonspecific beta-blockers. These effects on the metabolite are not expected to be of clinical consequence.

Yes. Some lifestyle and psychological factors can play a role in causing ED, such as smoking, drinking, and stress because they may lead to conditions that affect blood circulation. 

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